MovDisordV3, Main, Exploration, bibRecord, 000669

Alpha-synuclein REP1 variants and survival in Parkinson’s disease

Identifieur interne : 000669 ( Main/Exploration ); précédent : 000668; suivant : 000670

Alpha-synuclein REP1 variants and survival in Parkinson’s disease

Auteurs : Sun Ju Chung [Corée du Sud] ; Joanna M. Biernacka [États-Unis] ; Sebastian M. Armasu [États-Unis] ; Kari Anderson [États-Unis] ; Roberta Frigerio [États-Unis] ; Jan O. Aasly [Norvège] ; Grazia Annesi [Italie] ; Anna Rita Bentivoglio [Italie] ; Laura Brighina [Italie] ; Marie-Christine Chartier-Harlin [France] ; Stefano Goldwurm [Italie] ; Georgios Hadjigeorgiou [Grèce] ; Barbara Jasinska-Myga [Pologne, États-Unis] ; Beom Seok Jeon [Corée du Sud] ; Yun Joong Kim [Corée du Sud] ; Rejko Krüger [Allemagne] ; Suzanne Lesage [France] ; Katerina Markopoulou [États-Unis] ; George Mellick [Australie] ; Karen E. Morrison ; Andreas Puschmann [Suède] ; Eng-King Tan [Singapour] ; Jessie Theuns [Belgique] ; Karin Wirdefeldt [Suède] ; Zbigniew K. Wszolek [États-Unis] ; Alexis Elbaz [France] ; Demetrius M. Maraganore [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.

RBID : PMC:4172351

English descriptors

KwdEn :
- Adult, Age of Onset, Aged, Aged, 80 and over, Dinucleotide Repeats (genetics), Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease (genetics), Genotype, Humans, International Cooperation, Male, Middle Aged, Parkinson Disease (genetics), Parkinson Disease (mortality), Survival, alpha-Synuclein (genetics).
MESH :
- chemical , genetics : alpha-Synuclein.
- genetics : Dinucleotide Repeats, Genetic Predisposition to Disease, Parkinson Disease.
- mortality : Parkinson Disease.
- Adult, Age of Onset, Aged, Aged, 80 and over, Female, Gene Frequency, Genetic Association Studies, Genotype, Humans, International Cooperation, Male, Middle Aged, Survival.

Abstract

Objectives

To determine if alpha-synuclein REP1 genotypes are associated with survival in Parkinson’s disease.

Methods

Investigators from the Genetic Epidemiology of Parkinson’s Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.

Results

Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in Parkinson’s disease. However, there was a significant association between REP1 genotypes and age at onset of PD (Hazard Ratio = 1.06, 95% Confidence Interval = 1.01–1.10, p value = 0.01).

Conclusions

In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in Parkinson’s disease. Further studies of α–synuclein’s role in disease progression and long-term outcomes are needed.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172351

DOI: 10.1002/mds.25841
PubMed: 24578302
PubMed Central: 4172351

Affiliations:

Allemagne, Australie, Belgique, Corée du Sud, France, Grèce, Italie, Norvège, Pologne, Singapour, Suède, États-Unis
Bade-Wurtemberg, District de Tübingen, Floride, Illinois, Latium, Lombardie, Minnesota, Province d'Anvers, Svealand, Trøndelag, Île-de-France
Anvers, Lille, Milan, Paris, Rome, Stockholm, Séoul, Trondheim, Tübingen, Villejuif
Université d'Anvers

Le document en format XML

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<author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
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<author><name sortKey="Markopoulou, Katerina" sort="Markopoulou, Katerina" uniqKey="Markopoulou K" first="Katerina" last="Markopoulou">Katerina Markopoulou</name>
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<author><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E." last="Morrison">Karen E. Morrison</name>
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<author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name>
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<author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore General Hospital, National Neuroscience Institute, Singapore</wicri:regionArea>
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<author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name>
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<affiliation wicri:level="4"><nlm:aff id="A24">Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff>
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<author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea>
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<author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Department of Neurology, Mayo Clinic, Jacksonville, FL USA</nlm:aff>
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<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea>
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<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
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<affiliation wicri:level="3"><nlm:aff id="A28">Univ Versailles St-Quentin, UMRS 1018, F-94807, Villejuif, France</nlm:aff>
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<author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, NorthShore University HealthSystem, Evanston, IL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Alpha-synuclein REP1 variants and survival in Parkinson’s disease</title>
<author><name sortKey="Chung, Sun Ju" sort="Chung, Sun Ju" uniqKey="Chung S" first="Sun Ju" last="Chung">Sun Ju Chung</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
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<author><name sortKey="Biernacka, Joanna M" sort="Biernacka, Joanna M" uniqKey="Biernacka J" first="Joanna M." last="Biernacka">Joanna M. Biernacka</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Health Sciences Research, Mayo Clinic, Rochester, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</placeName>
<wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Rochester</wicri:cityArea>
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<author><name sortKey="Armasu, Sebastian M" sort="Armasu, Sebastian M" uniqKey="Armasu S" first="Sebastian M." last="Armasu">Sebastian M. Armasu</name>
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</placeName>
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<author><name sortKey="Anderson, Kari" sort="Anderson, Kari" uniqKey="Anderson K" first="Kari" last="Anderson">Kari Anderson</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
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<author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name>
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<country xml:lang="fr">Norvège</country>
<wicri:regionArea>St. Olav’s Hospital, Department of Neurology, Trondheim</wicri:regionArea>
<placeName><settlement type="city">Trondheim</settlement>
<region type="région" nuts="2">Trøndelag</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Institute of Neurological Sciences, National Research Council, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Neurological Sciences, National Research Council</wicri:regionArea>
<wicri:noRegion>National Research Council</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Neurology, Catholic University, Rome, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, Catholic University, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Neurology, San Gerardo Hospital, Monza, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, San Gerardo Hospital, Monza</wicri:regionArea>
<wicri:noRegion>Monza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Inserm UMR837, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm UMR837, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation><nlm:aff id="A9">Univ Lille Nord de France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name>
<affiliation wicri:level="3"><nlm:aff id="A10">Parkinson Institute, IstitutiClinici di Perfezionamento, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Parkinson Institute, IstitutiClinici di Perfezionamento, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hadjigeorgiou, Georgios" sort="Hadjigeorgiou, Georgios" uniqKey="Hadjigeorgiou G" first="Georgios" last="Hadjigeorgiou">Georgios Hadjigeorgiou</name>
<affiliation wicri:level="1"><nlm:aff id="A11">Faculty of Medicine, University of Thessalia, Larissa, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Faculty of Medicine, University of Thessalia, Larissa</wicri:regionArea>
<wicri:noRegion>Larissa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A13">Department of Neurology, Mayo Clinic, Jacksonville, FL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jeon, Beom Seok" sort="Jeon, Beom Seok" uniqKey="Jeon B" first="Beom Seok" last="Jeon">Beom Seok Jeon</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Seoul National University Hospital, Seoul, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Seoul National University Hospital, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kim, Yun Joong" sort="Kim, Yun Joong" uniqKey="Kim Y" first="Yun Joong" last="Kim">Yun Joong Kim</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Department of Neurology, Hallym University, Seoul, Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Hallym University, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name>
<affiliation wicri:level="3"><nlm:aff id="A16">Center of Neurology and Hertie-Institute for Clinical Brain Research, Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center of Neurology and Hertie-Institute for Clinical Brain Research, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
<affiliation wicri:level="1"><nlm:aff id="A17">Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelleépinière, UMR-S975; Inserm, U975, Cnrs, UMR 7225, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Pierre et Marie Curie-Paris6, Centre de Recherche de l’Institut du Cerveau et de la Moelleépinière, UMR-S975; Inserm, U975, Cnrs, UMR 7225, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Markopoulou, Katerina" sort="Markopoulou, Katerina" uniqKey="Markopoulou K" first="Katerina" last="Markopoulou">Katerina Markopoulou</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, NorthShore University HealthSystem, Evanston, IL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mellick, George" sort="Mellick, George" uniqKey="Mellick G" first="George" last="Mellick">George Mellick</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD</wicri:regionArea>
<wicri:noRegion>QLD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E." last="Morrison">Karen E. Morrison</name>
<affiliation><nlm:aff id="A20">School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham UK</nlm:aff>
<wicri:noCountry code="subfield">Birmingham UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Section of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Section of Neurology, Department of Clinical Sciences, Lund University, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore General Hospital, National Neuroscience Institute, Singapore</wicri:regionArea>
<wicri:noRegion>Singapore</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name>
<affiliation wicri:level="1"><nlm:aff id="A23">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea>
<wicri:noRegion>Antwerp</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A24">Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName><settlement type="city">Anvers</settlement>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name>
<affiliation wicri:level="3"><nlm:aff id="A25">Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Department of Neurology, Mayo Clinic, Jacksonville, FL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<affiliation wicri:level="3"><nlm:aff id="A27">Inserm, Centre for Research in Epidemiology and Population Health, U1018, Social and occupational determinants of health, F-94807, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm, Centre for Research in Epidemiology and Population Health, U1018, Social and occupational determinants of health, F-94807, Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A28">Univ Versailles St-Quentin, UMRS 1018, F-94807, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ Versailles St-Quentin, UMRS 1018, F-94807, Villejuif</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Villejuif</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Neurology, NorthShore University HealthSystem, Evanston, IL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Dinucleotide Repeats (genetics)</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Association Studies</term>
<term>Genetic Predisposition to Disease (genetics)</term>
<term>Genotype</term>
<term>Humans</term>
<term>International Cooperation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (mortality)</term>
<term>Survival</term>
<term>alpha-Synuclein (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dinucleotide Repeats</term>
<term>Genetic Predisposition to Disease</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Association Studies</term>
<term>Genotype</term>
<term>Humans</term>
<term>International Cooperation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Survival</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title>
<p id="P1">To determine if alpha-synuclein REP1 genotypes are associated with survival in Parkinson’s disease.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Investigators from the Genetic Epidemiology of Parkinson’s Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in Parkinson’s disease. However, there was a significant association between REP1 genotypes and age at onset of PD (Hazard Ratio = 1.06, 95% Confidence Interval = 1.01–1.10, <italic>p</italic>
 value = 0.01).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in Parkinson’s disease. Further studies of α–synuclein’s role in disease progression and long-term outcomes are needed.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Belgique</li>
<li>Corée du Sud</li>
<li>France</li>
<li>Grèce</li>
<li>Italie</li>
<li>Norvège</li>
<li>Pologne</li>
<li>Singapour</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>District de Tübingen</li>
<li>Floride</li>
<li>Illinois</li>
<li>Latium</li>
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<li>Minnesota</li>
<li>Province d'Anvers</li>
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<li>Trøndelag</li>
<li>Île-de-France</li>
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<settlement><li>Anvers</li>
<li>Lille</li>
<li>Milan</li>
<li>Paris</li>
<li>Rome</li>
<li>Stockholm</li>
<li>Séoul</li>
<li>Trondheim</li>
<li>Tübingen</li>
<li>Villejuif</li>
</settlement>
<orgName><li>Université d'Anvers</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E." last="Morrison">Karen E. Morrison</name>
</noCountry>
<country name="Corée du Sud"><noRegion><name sortKey="Chung, Sun Ju" sort="Chung, Sun Ju" uniqKey="Chung S" first="Sun Ju" last="Chung">Sun Ju Chung</name>
</noRegion>
<name sortKey="Jeon, Beom Seok" sort="Jeon, Beom Seok" uniqKey="Jeon B" first="Beom Seok" last="Jeon">Beom Seok Jeon</name>
<name sortKey="Kim, Yun Joong" sort="Kim, Yun Joong" uniqKey="Kim Y" first="Yun Joong" last="Kim">Yun Joong Kim</name>
</country>
<country name="États-Unis"><region name="Minnesota"><name sortKey="Biernacka, Joanna M" sort="Biernacka, Joanna M" uniqKey="Biernacka J" first="Joanna M." last="Biernacka">Joanna M. Biernacka</name>
</region>
<name sortKey="Anderson, Kari" sort="Anderson, Kari" uniqKey="Anderson K" first="Kari" last="Anderson">Kari Anderson</name>
<name sortKey="Armasu, Sebastian M" sort="Armasu, Sebastian M" uniqKey="Armasu S" first="Sebastian M." last="Armasu">Sebastian M. Armasu</name>
<name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name>
<name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name>
<name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name>
<name sortKey="Markopoulou, Katerina" sort="Markopoulou, Katerina" uniqKey="Markopoulou K" first="Katerina" last="Markopoulou">Katerina Markopoulou</name>
<name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
</country>
<country name="Norvège"><region name="Trøndelag"><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name>
</region>
</country>
<country name="Italie"><noRegion><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name>
</noRegion>
<name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
<name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name>
<name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name>
</country>
<country name="France"><noRegion><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name>
</noRegion>
<name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
</country>
<country name="Grèce"><noRegion><name sortKey="Hadjigeorgiou, Georgios" sort="Hadjigeorgiou, Georgios" uniqKey="Hadjigeorgiou G" first="Georgios" last="Hadjigeorgiou">Georgios Hadjigeorgiou</name>
</noRegion>
</country>
<country name="Pologne"><noRegion><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name>
</noRegion>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name>
</region>
</country>
<country name="Australie"><noRegion><name sortKey="Mellick, George" sort="Mellick, George" uniqKey="Mellick G" first="George" last="Mellick">George Mellick</name>
</noRegion>
</country>
<country name="Suède"><noRegion><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name>
</noRegion>
<name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name>
</country>
<country name="Singapour"><noRegion><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name>
</noRegion>
</country>
<country name="Belgique"><noRegion><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name>
</noRegion>
<name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name>
</country>
</tree>
</affiliations>
</record>

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       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3

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Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Alpha-synuclein REP1 variants and survival in Parkinson’s disease

Alpha-synuclein REP1 variants and survival in Parkinson’s disease

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Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.